Expression of protamine-1 and -2 mRNA during human spermiogenesis
نویسندگان
چکیده
منابع مشابه
Expression of protamine-1 and -2 mRNA during human spermiogenesis.
During spermiogenesis, the histone-to-protamine replacement causes the compaction of the spermatid chromatin. The genes for protamines, PRM-1 and PRM-2, are transcribed in round and elongating spermatids. The transcripts are stored in a translationally-repressed state by the binding of protein repressors before being translated in elongating and elongated spermatids. RNA extracts from homogeniz...
متن کاملComparison of Protamine 1 to Protamine 2 mRNA Ratio and YBX2 gene mRNA Content in Testicular Tissue of Fertile and Azoospermic Men
Background Although aberrant protamine (PRM) ratios have been observed in infertile men, the mechanisms that implicit the uncoupling of PRM1 and PRM2 expression remain unclear. To uncover these mechanisms, in this observational study we have compared the PRM1/PRM2 mRNA ratio and mRNA contents of two regulatory factors of these genes. MaterialsAndMethods In this experimental study, sampling was ...
متن کاملcomparison of protamine 1 to protamine 2 mrna ratio and ybx2 gene mrna content in testicular tissue of fertile and azoospermic men
background: although aberrant protamine (prm) ratios have been observed in infertile men, the mechanisms that implicit the uncoupling of prm1 and prm2 expression remain unclear. to uncover these mechanisms, in this observational study we have compared the prm1/prm2 mrna ratio and mrna contents of two regulatory factors of these genes. materials and methods: in this experimental study, sampling ...
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Background: The Fc receptor like (FCRL) molecules belong to the immunoglobulin (Ig) superfamily with potentially immunoregulatory <span style="font-va...
متن کاملTSSK6 is required for γH2AX formation and the histone-to-protamine transition during spermiogenesis.
Spermiogenesis includes transcriptional silencing, chromatin condensation and extensive morphological changes as spermatids transform into sperm. Chromatin condensation involves histone hyperacetylation, transitory DNA breaks, histone H2AX (also known as H2AFX) phosphorylation at Ser139 (γH2AX), and replacement of histones by protamines. Previously, we have reported that the spermatid protein k...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2000
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/6.3.219